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Benzoyl peroxide

IntroductionBenzoyl peroxide (BPO, CAS 94-36-0) is a widely used organic compound with strong o

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İçerik

İçeri

Benzoyl peroxide (BPO, CAS 94-36-0) is a widely used organic compound with strong oxidizing properties. Primarily known for its role in acne treatment, it also serves as a bleaching agent, polymerization initiator, and industrial disinfectant. This article presents key data in tabular form for quick reference.

1. Chemical & Physical Properties

PropertySpecification
Chemical FormulaC₁₄H₁₀O₄
Moleküler Taşımı242.23 g/mol
GörüntüWhite crystalline powder or granules
OdorFaint, pungent
Erime noktası103–105°C (decomposes)
ÇözünürlükInsoluble in water; soluble in acetone, chloroform
KararlılıkHeat- and shock-sensitive (store at ≤25°C)
Active Oxygen Content~5.9% (for 99% purity)

Key Characteristics:

✔ Strong oxidizer – Releases free radicals upon decomposition

✔ Concentration-dependent effects – 2.5% to 10% in medical use

2. Applications by Industry

IndustryPrimary UseTypical Concentration
PharmaceuticalsTopical acne treatment (gels, creams)2.5%–10%
CosmeticsTeeth whitening, hair bleaching3%–6%
Plastics & RubberPolymerization initiator (PVC, polyester)0.1%–2%
Food IndustryFlour bleaching (banned in some regions)15–50 ppm
TextilesFabric bleaching and stain removal1%–5% aqueous solution

3. Safety & Handling Protocols

ParameterGuideline
StorageCool (≤25°C), dry, away from metals & amines
Personal ProtectionNitrile gloves, goggles, and lab coat
Yangın TehlikesiMay ignite at 80°C; use water spray (not foam)
First Aid (Skin Contact)Wash with soap/water; avoid alcohol-based cleansers
Environmental ImpactToxic to aquatic life (avoid direct release)

Regulatory Status:

FDA (US): Approved for OTC acne products (≤10%)

EU: Restricted in cosmetics (R36/38 irritant label)

OSHA PEL: 5 mg/m³ (8-hour TWA)

4. Comparison with Alternative Oxidizers

PropertyBenzoyl PeroxideHydrogen PeroxideSalicylic Acid
Primary UseAcne, polymerizationDisinfection, bleachingAcne, exfoliation
MechanismFree radical oxidationOxidizing agentKeratolytic
Skin IrritationModerate to highHighLow to moderate
KararlılıkHeat-sensitiveUnstable (decomposes)Stable

Sonuç

Benzoyl peroxide is a multifunctional oxidizer with critical roles in dermatology and industrial processes. While effective, its reactive nature demands careful handling. Future trends include microencapsulated formulations to reduce skin irritation in medical applications.

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